Last update:
   07-Jul-2004
 

Arch Hellen Med, 21(1), January-February 2004, 41-45

SHORT COMMUNICATION

Αssociation of multiple sclerosis with monoclonal gammopathy
of undetermined significance

M. RENTZOS, C. GOTOSIDIS, A. KAPONI, A. BONAKIS, C. KILINTIREAS
Neurologic Clinic, University of Athens, “Εginiteio” Hospital, Athens, Greece

The cases are presented of two patients with monoclonal gammopathy of undetermined significance (MGUS) associated with multiple sclerosis (MS). MGUS is the result of a plasma cell clone escaping normal control. MS is a demyelinative disease in which there is evidence of CD4 dependent B-cell activation. Their association could be the result of a causal link between these disorders or it may be a fortuitous phenomenon.

Key words: Causal link, MGUS, MS.

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