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Arch Hellen Med, 28(4), July-August 2011, 439-449


Clinical manifestations of disturbances in granulopoiesis kinetics: Idiosyncratic agranulocytosis

J. Meletis , L. Papageorgiou
First Department of Internal Medicine, National and Kapodistrian University of Athens, "Laiko" General Hospital of Athens, Athens, Greece

This review covers the kinetics of granulopoiesis, the functions and apoptosis of the granulocytes and the metabolism of the granulocyte series, along with a report of the various different drugs that cause alterations in the numbers of granulocytes. The mechanisms of drug induced idiosyncratic agranulocytosis are described, especially those activated after treatment with aminopyrine, amiodarone and clozapine.

Key words: Agranulocytosis, Aminopyrine, Amiodarone, Clozapine, Granulocyte kinetics.

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