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Arch Hellen Med, 32(5), September-October 2015, 576-582


Chronic obstructive pulmonary disease and periodontitis: Fact or fiction?

A. Spiropoulou, D. Lykouras, M. Lykouras, K. Spiropoulos
Department of Pulmonary Medicine, University Hospital of Patras, Rio, Patras, Greece

Chronic periodontitis and chronic obstructive pulmonary disease (COPD) are both characterized by neutrophilic inflammation and connective tissue damage. Although current data suffice to support a connection between the two diseases, their common mechanisms are yet to be elucidated. Study of the pathophysiology of the connection between periodontitis and COPD may lead to the development of new treatment and improved prognosis. Epidemiological data may also show a connection between the two conditions. The neutrophilic inflammation in COPD and periodontitis is orchestrated by CD8 lymphocytes and macrophages, leading to the aggregation of neutrophils and affecting the balance of proteases and antiproteases. The management of COPD and periodontitis may have common aspects. Finally, further research is needed to elucidate the co-morbidity of the two conditions with a view to improving the therapeutic management and prognosis.

Key words: Chronic obstructive pulmonary disease (COPD), CD8, Emphysema, Macrophages, Neutrophils, Periodontitis.

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