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Arch Hellen Med, 34(2), March-April 2017, 181-190


The action of statins through the mevalonate pathway and its impact on the main human systems

G. Bazoukis, S. Savvanis, A. Yalouris
Department of Internal Medicine, "Elpis" General Hospital of Athens, Athens, Greece

Since their introduction, statins have played a crucial role in the primary and secondary prevention of cardiovascular death. Statins act by blocking the mevalonate pathway, contributing to reduction in cholesterol synthesis. Statins block a number of different branches of the mevalonate pathway leading to the various actions of these drugs, but also to their adverse effects. This is a review of the consequences of mevalonate pathway blocking, with current data on the impact of statins in the various systems of the human body.

Key words: HMG CoA reductase inhibitors, Mevalonate pathway, Statins.

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