Disseminated Candida albicans
infection in a patient with hereditary myeloperoxidase deficiency
A 52 year old female presented with a fever of 390
C, painful hyperpigmented skin lesions, malaise, sore mucosae
and dysphagia of 1 week's duration. There were palpable painful
large inflammatory nodules in the involved skin areas. Laboratory
findings were ESR 127/132, Ht 39%, WBC 23.600/μL (neutrophils
74% with some degree of hypogranulation and vacuolation) and diffuse
hypergammaglobulinemia. Bone marrow aspiration revealed hyperplasia
of the granulocytic series. Despite the intensive antibiotic therapy
applied, the outcome was fatal a few days following admission,
in a picture of septic shock. Fungi were detected in blood cultures.
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