17 Kallirrois str., GR-117 43 ATHENS,
GREECE, Ôel: +30210-92 14 325, Fax: +30210-92 14 204, E-mail: stomsoc@otenet.gr
|
|
|
|
Stomatologia 2006, 63(4):159-169
Review
PARTIAL BIOPSY AND METASTATIC SPREAD IN ORAL SQUAMOUS CELL CARCINOMA.
REVIEW OF THE LITERATURE
K.I. TOSIOS, K. CHOUPIS, S.I. PAPANICOLAOU
SUMMARY The standard method for the diagnosis of oral squamous cell carcinoma, is partial biopsy and pathologic examination. Partial biopsy is considered, as a rule, a simple and safe surgical procedure. The hypothesis that the trauma incited on the neoplasm may facilitate the shedding of malignant cells beyond the tumor boundaries is reasonable. Other factors associated with the trauma or the healing process, such as the release of growth factors, may facilitate local or metastatic spread of the tumor, and may have an adverse effect on prognosis. In the present paper the literature on the role of partial biopsy on the metastatic spread of oral squamous cell carcinoma is reviewed. From the pertinent in vitro and in vivo studies published up to date it is concluded that the risk of metastatic spread by a lege artis partial biopsy outweighs the risks of “non-diagnosis” or false diagnosis, and that partial biopsy continues to be the “gold standard” for the diagnosis of oral cancer. However, well-conducted, prospective, randomized studies examining the effect of partial biopsy on prognosis, frequency and time-interval to recurrence, or frequency of metastases are lacking. The role of the clinician is not only limited to early diagnosis of oral cancer, but is also extended to the early and quick reference of the patient for treatment. Since the possibility of metastasis and evidence of local dissemination of the cancer cells under partial biopsy necessitate immediate treatment of the primary lesion.
KEY WORDS: Biopsy, Safety, Adverse effects, Neoplasm metastasis, Mouth neoplasms, Squamous cell carcinoma, oral.
 |
TABLE
OF CONTENTS PAST
ISSUES INSTRUCTIONS
FOR THE AUTHORS
