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�� fludarabine �� 2-�� (2-CdA) �� DNA �� .^1�5 � �� -�� (NST).⁶ H �� 2-Cd� �� 2-CdA ��.

In vitro �� (�) � �� -�� (NST) �� (��) �� , (�) � �� NST-�� S-��, (�) � �� (��) �� bcl-2-�� .^7,8 �� bcl-2 �� .^9,10

�� 2-CdA �� bcl-2, �� in vitro �� .¹¹

�� , �� 2-CdA. �� 2-CdA, �� .

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�� 72 �� , � �� 2-�� .

� �� , �� 40 ��, �� 30�� 10��. ��, �� .

�� Rai, �� , �� , �� 40% �� , �� 2-CdA. �� , �� , �� .

�� , �� , �� , �� .

� �� (Ht) 23%, �� 12.600/�L, �� 120.000/�L, �� LDH (1030 U�/mL) �� (11,8 mg/dL).

� �� , �� Dukes.

� �� , �� , �� t 34%, �� 9.800/�L, �� 150.000/�L �� .

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� �� 2-CdA �� , �� 2-CdA. � �� in situ �� , � �� , �� , �� . � �� , ��, �� , �� .¹² �� , �� (��) �� .¹³

�� in vitro �� (��) �� bcl-2-�� , ��, �� bcl-2-��, �� , �� .¹ �� bcl-2 �� .

�� 2 �� 2-CdA �� , �� , �� , �� in vivo �� , �� 2-CdA, �� , �� .

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�� in situ �� , �� . �� , �� , �� de novo �� .

� �� , �� in situ �� .

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