Last update:
10-Jun-2025

Castleman disease is a difficult diagnosis, even based on histopathological and immunohistochemical data from samples of the lesions. We report a case of a previously healthy male patient at the age of 57 years, who underwent the evaluation to clear the origin of a hypervascular mass with calcifications in the pancreatic area. Initial challenging interpretation of routine laboratory determinations and imaging studies, besides the histopathological and immunohistochemical data are commented on. The final diagnosis of Castleman disease was established after the procedure of corporal-caudal pancreatectomy associated with splenectomy performed by laparoscopy. Even single cases may enhance the awareness and suspicion index among non-specialist health care workers about the Castleman disease mimicking a primary neuroendocrine tumor.

Key words: Castleman disease, Diagnosis, Pancreatic neoplasia, Treatment.