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05-Jul-2026
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Arch Hellen Med, 43(5), September-October 2026, 707-709 CASE REPORT Lithium toxicity in a patient with Parkinson's disease and bipolar disorder R. Giannas,1 L. Klironomou,2 E. Skafida3 |
A 69-year-old female who developed lithium toxicity with both neurological and systemic manifestations. The toxicity followed the concurrent use of levodopa/benserazide and pramipexole along with chronic lithium therapy. The patient had a history of recent Parkinson's disease diagnosis and chronic bipolar disorder, and her complex pharmacological regimen posed significant diagnostic and therapeutic challenges. Elderly patients with neurodegenerative and psychiatric comorbidities are particularly vulnerable to adverse drug interactions due to polypharmacy and age-related renal decline. In this case, lithium toxicity progressed rapidly, leading to renal impairment, rhabdomyolysis, and ultimately death. This case highlights the importance of close clinical monitoring, early recognition of toxicity signs, and coordination among healthcare providers, when coadministering Parkinson's disease therapy with lithium in high-risk populations.
Key words: Bipolar disorder, Lithium toxicity, Parkinson's disease, Polypharmacy, Rhabdomyolysis.
