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Arch Hellen Med, 28(2), March-April 2011, 219-223


Genetic polymorphism A1675G of the angiotensin type 2 receptor and its role in hypertension

N. Koumallos, D. Tousoulis, C. Antoniades, A.S. Antonopoulos, C. Stefanadis
First Department of Cardiology, "Hippokration" General Hospital of Athens, Medical School, University of Athens, Athens, Greece

The angiotensin type 2 receptor (AT2R) plays a crucial role in the regulation of blood pressure and atherogenesis. The AT2R gene is located on chromosome X and the biological effect of polymorphism A1675G in this gene still needs to be further specified. This is a review of all the studies examining the role of A1675G in arterial hypertension and cardiac disease.

Key words: Angiotensin, Atherosclerosis, Hypertension, Inflammation.

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