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Arch Hellen Med, 28(2), March-April 2011, 267-269


Correlation of the lipid profile and bone metabolism biomarkers in premature infants with osteopenia

C. Tsakalidis, C. Dokos, A. Kalesi, N. Nikolaidis
Second Clinic of Neonatology, "Papageorgiou" Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

OBJECTIVE The lipid profile of preterm infants appears to be an important factor in the pathogenesis of metabolic diseases. The purpose of this study was to explore the possible correlation between lipid parameters and markers of bone metabolism.

METHOD The study group comprised 20 osteopenic premature newborn infants with gestational age (GA) <34 weeks. Demographic data (gender, gestational week) and somatometric data (body weight) were recorded and measurements were made of levels of biochemical markers of bone metabolism [alkaline phosphatase (ALP), calcium (Ca), phosphorus (P), magnesium (Mg)] and serum total cholesterol (TC) and triglyceride (TG).

RESULTS The findings of an increased mean level of ALP (878.8±112.89 IU/mL) and decreased level of serum P (4.93±0.719 mg/dL) are in agreement with the current literature reports of premature infants with osteopenia. Statistical analysis demonstrated that the TC and serum Ca may be related to the weight of osteopenic newborn infants.

CONCLUSIONS The determination of serum ALP and P and monitoring of the weight of preterm infants are essential for the diagnosis of osteopenia. Further study is needed on the fractions of TC for elucidation of the correlation of the lipid profile with osteopenia of prematurity in infants.

Key words: Bone metabolism, Lipids, Osteopenia, Premature neonates.

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